Contact

Contact

Richard Sandberg, CEO & Co-Chairman
(203) 966-6934
dsandberg@resolysbio.com

 

John McMichael, Ph.D., President & Co-Chairman
(518) 872-1144
jm@resolysbio.com

Notes

1    In its natural non-oxidized state and at concentrations 10,000 times higher than used by Resolys, Streptolysin O is the principal cause of the sore throat associated with strep infections.
2   Many would describe the dosage safety profile using the Therapeutic Index (“TI”) calculated as the toxic dose of a drug divided by the effective dose.  Our calculation is a hybrid based on the toxic dose of natural SLO divided by the effective dose of oSLO.  That ratio exceeds 50,000 vs a TI of less than 50 for aspirin and acetaminophen.  
3   https://www.cdc.gov/traumaticbraininjury/pdf/TBI-Surveillance-Report-FINAL_508.pdf reports approximately 2.9 million TBI-related ED visits, hospitalizations and deaths in 2014 
4   Lo, J.,et.  al., from the Rehabilitation Medicine Department, National Institutes of Health, Bethesda, MD, Archives of Physician Medicine and Rehabilitation, 2021; 124 reports multiple studies of TBI patients not returning the preinjury levels 1 year post-injury ranging from 33% to 50%
5   Victoroff, J, Bigler E., Concussion and Traumatic Encephalopathy (Kindle Locations 16800-17000), Cambridge University Press, Kindle Edition.  In a review of over 150 animal and human studies make a rough estimate that 40% of TBI patients do not return to preinjury levels 1 year post-injury. 
6   Langlois, JA et al, The Epidemiology and Impact of Traumatic Brain Injury, Journal of Head Trauma Rehabilitation: September 2006 – Volume 21 – Issue 5 – p 375-378 
7   Finkelstein, EA et.  al., The Incidence and Economic Burden of Injuries in the United States, Oxford University Press, 2006.
8   Company analysis
9   Hiploylee, C.  et al; Longitudinal Study of Postconcussion Syndrome: Not Everyone Recovers, Journal of Neurotrauma, Vol 34: pp 1511-1523, April 15, 2017 [https://doi.org/10.1089/neu.2016.4677]
10   Heinzelmann M, Imhof HG, Trentz O (2004) [Shock trauma room management of the multiple-traumatized patient with skull-brain injuries, A systematic review of the literature].  Unfallchirurg 107:871-880. 
11  1McInnes K, Friesen CL, MacKenzie DE, Westwood DA, Boe SG (2017) Mild Traumatic Brain Injury (mTBI) and chronic cognitive impairment: A scoping review.  PLoS ONE 12(4): e0174847
12   CDC, https://www.cdc.gov/traumaticbraininjury/pdf/moderate_to_severe_tbi_lifelong-a.pdf
13   Saef, I et al.; Concussion and Risk of Chronic Medical and Behavioral Health Comorbidities, Journal of Neurotrauma, Volume 38, No.  13, June 10, 2021 [https:  doi.org/10.1089/neu.2020.7484] 
14   Rabinowitz, A; Watanabe, T.  Pharmacotherapy for Treatment of Cognitive and Neuropsychiatric Symptoms after mTBI, Journal Head Trauma and Rehabilitation, Vol.  35, No.  1, pp76-83