Chronic Tissue Disorders

Chronic Tissue Disorders

Physicians familiar with the work of Beech Tree Labs and Resolys Bio asked scientists to focus
on a condition for which there is no well-established therapy – hypermobile Ehlers-Danlos
Syndromes (hEDS). This is generally regarded as a genetic condition which is evidenced not
only by “loose joints” (hypermobility) but also by chronic pain and fatigue.

Ehlers-Danlos Syndromes comprise more than a dozen genetic disorders that cause defective
processing of collagen and, as a result, weakened or defective connective tissues in the body. As
a broad generalization, these disorders reduce the strength and increase the elasticity of
connective tissues in the body’s frame (particularly those holding joints together) and may create
life threatening flaws or weaknesses in the structure and performance of organs such as kidneys,
intestines, and blood vessels.

Joints that are not held together firmly by normal connective tissue characterize hEDS where
patients experience frequent dislocations, pain from dislocations, and inflammation. Many who
suffer with this condition also report fatigue because muscles are working overtime to keep the
body together.

As there is no known cure, treatment for the pain and fatigue associated with hypermobility
generally emphasizes physical support and muscle development to support loose joints. Physical
therapy, bracing, and casting may help strengthen muscles and shore up joints, but progressive
disease often leads to wheelchairs and permanent incapacitation. Aquatic therapy promotes
muscular development and coordination but does not address the lack of joint support.

Genetic testing has associated specific mutations with certain varieties of EDS, and physicians
have defined seven types by both their genetic and symptomatic characteristics. However, hEDS
has not yet been clearly linked to a genetic marker. Furthermore, it is not yet clear whether other
forms of Joint Hypermobility Syndromes that are accompanied by pain and fatigue may also
respond to MCC. Without proper testing and evaluation, afflicted patients are often
misdiagnosed with hypochondriasis, depression, or chronic fatigue syndrome.